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Maria Nesterova Selected Research

Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)

1/2017Celecoxib treatment of fibrous dysplasia (FD) in a human FD cell line and FD-like lesions in mice with protein kinase A (PKA) defects.
9/2014Differentially regulated protein kinase A (PKA) activity in adipose tissue and liver is associated with resistance to diet-induced obesity and glucose intolerance in mice that lack PKA regulatory subunit type IIα.
3/2012In vitro studies of novel PRKAR1A mutants that extend the predicted RIα protein sequence into the 3'-untranslated open reading frame: proteasomal degradation leads to RIα haploinsufficiency and Carney complex.
1/2011Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype.
1/2011Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors.
10/20098-Cl-adenosine inhibits proliferation and causes apoptosis in B-lymphocytes via protein kinase A-dependent and independent effects: implications for treatment of Carney complex-associated tumors.
4/2009MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling.
5/2008In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay.
5/2008Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors.
3/2008Protein kinase A-independent inhibition of proliferation and induction of apoptosis in human thyroid cancer cells by 8-Cl-adenosine.
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Maria Nesterova Research Topics

Disease

14Neoplasms (Cancer)
01/2017 - 06/2002
7Carney Complex
01/2017 - 01/2008
5Hyperplasia
01/2016 - 10/2008
5Cushing Syndrome
02/2014 - 10/2008
5Adenoma (Adenomas)
02/2014 - 07/2009
3Carcinogenesis
04/2009 - 09/2007
2Pituitary Neoplasms (Pituitary Adenoma)
02/2015 - 03/2012
2Obesity
09/2014 - 02/2014
2Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)
08/2013 - 07/2009
2Acth-Independent Macronodular Adrenal Hyperplasia
04/2011 - 08/2009
1Myxoma (Myxomas)
01/2017
1Hyperandrogenism
01/2016
1Insulin Resistance
01/2016
1Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)
01/2016
1Glucose Intolerance
09/2014
1Testicular Germ Cell Tumor
08/2013
1Pituitary ACTH Hypersecretion
02/2013
1Polyostotic Fibrous Dysplasia (McCune Albright Syndrome)
04/2012
1Multiple Endocrine Neoplasia (Multiple Endocrine Adenomatosis)
03/2012
1Paraganglioma (Paragangliomas)
03/2012
1Pheochromocytoma
03/2012
1Renal Cell Carcinoma (Grawitz Tumor)
03/2012
1Seminoma
03/2012
1Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
03/2012
1Testicular Neoplasms (Testicular Cancer)
01/2011
1Prostatic Neoplasms (Prostate Cancer)
01/2011
1Cryopyrin-Associated Periodic Syndromes
01/2011
1Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)
08/2009
1Disease Progression
09/2008
1Ovarian Neoplasms (Ovarian Cancer)
09/2008
1Thyroid Neoplasms (Thyroid Cancer)
03/2008
1Aneuploidy (Aneuploid)
02/2008

Drug/Important Bio-Agent (IBA)

14Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
01/2017 - 06/2002
6Proteins (Proteins, Gene)FDA Link
08/2013 - 01/2008
4Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
01/2011 - 10/2008
3Hormones (Hormone)IBA
01/2016 - 08/2009
3Cyclic AMP (AMP, Cyclic)IBA
02/2014 - 05/2008
3AldosteroneIBA
02/2014 - 07/2009
3Hydrocortisone (Cortisol)FDA LinkGeneric
04/2012 - 07/2009
3Adrenocorticotropic Hormone (ACTH)FDA Link
04/2012 - 10/2008
3Messenger RNA (mRNA)IBA
05/2008 - 01/2008
2Dinoprostone (PGE2)FDA Link
01/2017 - 01/2011
2SteroidsIBA
01/2016 - 02/2013
2GlucocorticoidsIBA
01/2016 - 08/2009
2Growth Hormone (Somatotropin)IBA
02/2015 - 03/2012
2DNA (Deoxyribonucleic Acid)IBA
02/2012 - 08/2009
28-chloro-cyclic adenosine monophosphateIBA
03/2008 - 06/2002
2IsoenzymesIBA
09/2007 - 11/2004
1Celecoxib (Celebrex)FDA Link
01/2017
1Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
01/2017
1Dexamethasone (Maxidex)FDA LinkGeneric
01/2016
1AndrogensIBA
01/2016
1RNA (Ribonucleic Acid)IBA
08/2013
1LigandsIBA
08/2013
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
08/2013
1Protein Kinases (Protein Kinase)IBA
04/2012
1Succinate Dehydrogenase (Fumarate Reductase)IBA
03/2012
1OligonucleotidesIBA
04/2011
1Adenosine Monophosphate (AMP)IBA
01/2011
1InflammasomesIBA
01/2011
1Fumarate Hydratase (Fumarase)IBA
08/2009
1MicroRNAs (MicroRNA)IBA
04/2009
1Protein Isoforms (Isoforms)IBA
10/2008
1Biomarkers (Surrogate Marker)IBA
09/2008
1Adenosine (Adenocard)FDA LinkGeneric
05/2008
1Phosphotransferases (Kinase)IBA
05/2008
1Complementary DNA (cDNA)IBA
06/2002
1Transcription Factors (Transcription Factor)IBA
06/2002

Therapy/Procedure

2Adrenalectomy
02/2014 - 03/2012